Effective thermal management is a key for the continuous development of electronics, which are characteristics of modern life. It has a great effect on the lifetime, durability and reliability of these systems. A liquid-cooled micro channel heat sink is a compacted cooling part that used to provide better heat dissipation rates and low temperatures in electronic components. Nano fluids have been introduced as effective coolants to be employed in this type of heat sink to increase the heat dissipation rate. However, a comparative assessment of the thermal performance between commonly used nano fluids and water as coolants for micro channel heat sinks is still lacking. For this purpose, a computational fluid dynamics (CFD) analysis is performed to simulate and analyze the fluid flow and heat transfer.